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{"id":2507,"date":"2021-02-10T14:20:39","date_gmt":"2021-02-10T14:20:39","guid":{"rendered":"http:\/\/staging.careersinscience.co\/?p=2507"},"modified":"2021-02-25T09:12:15","modified_gmt":"2021-02-25T09:12:15","slug":"a-new-view-of-the-manhattan-plot","status":"publish","type":"post","link":"https:\/\/child.imagenscience.com\/archives\/2507","title":{"rendered":"A new view of the Manhattan plot"},"content":{"rendered":"\n

The human\u00a0genome\u00a0is almost identical from person to person, but we all have small differences which make us unique.
This can be as small as single changes in the nucleotide bases of\u00a0DNA, which are known as single nucleotide polymorphisms (SNPs).<\/p>\n\n\n\n

As well as contributing to our physical features, these changes can mean that certain individuals, or populations are more or less susceptible to a disease.
Genome-wide association studies (GWAS) aim to identify these differences, and usually present this complex data in a scatterplot known as a Manhattan plot.<\/p>\n\n\n\n

In this beautiful illustration of the Manhattan skyline :<\/p>\n\n\n\n

\ud83e\uddec Each window represents an SNP<\/p>\n\n\n\n

\ud83e\uddec The position along the x axis represents the genomic location<\/p>\n\n\n\n

\ud83e\uddec Each building represents a chromosome<\/p>\n\n\n\n

\ud83e\uddec The y axis shows the likelihood of a SNP being associated with the trait in question (the higher dot, the higher the probability)<\/p>\n\n\n\n

Thank you to \ud83c\uddfa\ud83c\uddf8 Gurmannat “Mannat” Kalra, molecular medicine PhD student at University of Maryland, Baltimore (UMB). Biology is her passion. Gurmannat creates interpretive paintings to make biological concepts easier to understand and remember.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"manhattan<\/figure>\n","protected":false},"excerpt":{"rendered":"

The buildings are chromosomes; each window is an SNP.<\/p>\n","protected":false},"author":2,"featured_media":2484,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[104],"tags":[],"_links":{"self":[{"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/posts\/2507"}],"collection":[{"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/comments?post=2507"}],"version-history":[{"count":4,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/posts\/2507\/revisions"}],"predecessor-version":[{"id":3117,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/posts\/2507\/revisions\/3117"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/media\/2484"}],"wp:attachment":[{"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/media?parent=2507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/categories?post=2507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/child.imagenscience.com\/wp-json\/wp\/v2\/tags?post=2507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}